Drugs that slow down the nervous system.

 In contrast to the initial effect of stimulants, which is an increase in arousal of the central nervous system, the effect of depressants is to impede the nervous system by causing nervous to fire more slowly. Small doses result in at least temporary feeling of intoxication- drunkenness-along with a sense of euphoria and joy.  When large amounts are taken, however, speech becomes slurred and muscle control becomes disjointed, making motion difficult. Ultimately, heavy users may lose consciousness entirely.

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